KEGG   NETWORK: N00365
Entry
N00365                      Network                                
Name
HPV E7 to cell cycle G1/S
Definition
E7 -> PSMC1 -> RB1
  Expanded
K21809 -> 5700 -> 5925
Class
nt06130 Cell cycle (viruses)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
5700  PSMC1; proteasome 26S subunit, ATPase 1
5925  RB1; RB transcriptional corepressor 1
Perturbant
K21809 (E7)  E7; HPV protein E7
Reference
PMID:9374493
  Authors
Berezutskaya E, Bagchi S
  Title
The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26 S proteasome.
  Journal
J Biol Chem 272:30135-40 (1997)
DOI:10.1074/jbc.272.48.30135
Reference
  Authors
zur Hausen H
  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
  Journal
J Natl Cancer Inst 92:690-8 (2000)
DOI:10.1093/jnci/92.9.690
Reference
  Authors
Narisawa-Saito M, Kiyono T
  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
  Journal
Cancer Sci 98:1505-11 (2007)
DOI:10.1111/j.1349-7006.2007.00546.x
Reference
  Authors
Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
  Title
The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
  Journal
Kobe J Med Sci 50:9-19 (2004)
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