KEGG   NETWORK: N00368
Entry
N00368                      Network                                
Name
HPV E5 to PDGFR-PI3K signaling pathway
Definition
E5 -> PDGFRB -> PI3K -> PIP3 -> AKT
  Expanded
K21812 -> 5159 -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06114 PI3K signaling (viruses)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
5159  PDGFRB; platelet derived growth factor receptor beta
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Perturbant
K21812 (E5)  E5; HPV protein E5
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:23731971
  Authors
DiMaio D, Petti LM
  Title
The E5 proteins.
  Journal
Virology 445:99-114 (2013)
DOI:10.1016/j.virol.2013.05.006
Reference
PMID:22078316
  Authors
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G
  Title
Papillomavirus E5: the smallest oncoprotein with many functions.
  Journal
Mol Cancer 10:140 (2011)
DOI:10.1186/1476-4598-10-140
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