 | | NETWORK: N00369 | |
| Entry |
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| Name |
HPV E5 to PDGFR-RAS-ERK signaling pathway
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| Definition |
E5 -> PDGFRB -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
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| Expanded |
K21812 -> 5159 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
nt06110 MAPK signaling (viruses and bacteria)
nt06166 Human papillomavirus (HPV)
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| Type |
Pathogen
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| Pathway |
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| Disease |
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| Gene |
| 5159 | PDGFRB; platelet derived growth factor receptor beta |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Perturbant |
| K21812 (E5) | E5; HPV protein E5 |
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| Reference |
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| Authors |
DiMaio D, Petti LM |
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| Title |
The E5 proteins. |
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| Journal |
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| Reference |
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| Authors |
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G |
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| Title |
Papillomavirus E5: the smallest oncoprotein with many functions. |
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| Journal |
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| LinkDB |
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