 | | NETWORK: N00369 | |
Entry |
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Name |
HPV E5 to PDGFR-RAS-ERK signaling pathway
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Definition |
E5 -> PDGFRB -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
Expanded |
K21812 -> 5159 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
Class |
nt06110 MAPK signaling (viruses and bacteria)
nt06166 Human papillomavirus (HPV)
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Type |
Pathogen
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Pathway |
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Disease |
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Gene |
5159 | PDGFRB; platelet derived growth factor receptor beta |
2885 | GRB2; growth factor receptor bound protein 2 |
6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
3265 | HRAS; HRas proto-oncogene, GTPase |
3845 | KRAS; KRAS proto-oncogene, GTPase |
4893 | NRAS; NRAS proto-oncogene, GTPase |
369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
5594 | MAPK1; mitogen-activated protein kinase 1 |
5595 | MAPK3; mitogen-activated protein kinase 3 |
|
Perturbant |
K21812 (E5) | E5; HPV protein E5 |
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Reference |
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Authors |
DiMaio D, Petti LM |
Title |
The E5 proteins. |
Journal |
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Reference |
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Authors |
Venuti A, Paolini F, Nasir L, Corteggio A, Roperto S, Campo MS, Borzacchiello G |
Title |
Papillomavirus E5: the smallest oncoprotein with many functions. |
Journal |
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LinkDB |
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