KEGG   NETWORK: N00371
Entry
N00371                      Network                                
Name
HPV E7 to pyruvate generation
Definition
E7 -| PKM
  Expanded
K21809 -| 5315
Class
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
5315  PKM; pyruvate kinase M1/2
Perturbant
K21809 (E7)  E7; HPV protein E7
Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
  Journal
Proc Natl Acad Sci U S A 96:1291-6 (1999)
DOI:10.1073/pnas.96.4.1291
Reference
  Authors
Mazurek S, Zwerschke W, Jansen-Durr P, Eigenbrodt E
  Title
Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.
  Journal
Oncogene 20:6891-8 (2001)
DOI:10.1038/sj.onc.1204792
Reference
  Authors
Mazurek S, Zwerschke W, Jansen-Durr P, Eigenbrodt E
  Title
Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex.
  Journal
Biochem J 356:247-56 (2001)
DOI:10.1042/bj3560247
Reference
  Authors
Hardt PD, Mazurek S, Toepler M, Schlierbach P, Bretzel RG, Eigenbrodt E, Kloer HU
  Title
Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer.
  Journal
Br J Cancer 91:980-4 (2004)
DOI:10.1038/sj.bjc.6602033
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