NETWORK: N00411 Help
Entry
Name
HCMV UL33 to GNAS-AC-PKA signaling pathway
Definition
UL33 -> GNAS -> ADCY -> cAMP -> PKA -> CREB
Expanded
K22782 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586)
Class
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163 Human cytomegalovirus infection
Disease
H00368 Cytomegalovirus infection
Gene
2778 GNAS; GNAS complex locus
107 ADCY1; adenylate cyclase 1
108 ADCY2; adenylate cyclase 2
109 ADCY3; adenylate cyclase 3
196883 ADCY4; adenylate cyclase 4
111 ADCY5; adenylate cyclase 5
112 ADCY6; adenylate cyclase 6
113 ADCY7; adenylate cyclase 7
114 ADCY8; adenylate cyclase 8
115 ADCY9; adenylate cyclase 9
5566 PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567 PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568 PRKACG; protein kinase cAMP-activated catalytic subunit gamma
10488 CREB3; cAMP responsive element binding protein 3
1385 CREB1; cAMP responsive element binding protein 1
1386 ATF2; activating transcription factor 2
1388 ATF6B; activating transcription factor 6 beta
148327 CREB3L4; cAMP responsive element binding protein 3 like 4
468 ATF4; activating transcription factor 4
64764 CREB3L2; cAMP responsive element binding protein 3 like 2
84699 CREB3L3; cAMP responsive element binding protein 3 like 3
90993 CREB3L1; cAMP responsive element binding protein 3 like 1
9586 CREB5; cAMP responsive element binding protein 5
Perturbant
K22782 (UL33) UL33; Cytomegalovirus G-protein coupled receptor UL33
Metabolite
Reference
Authors
Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ
Title
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.
Journal
Reference
Authors
van Cleef KW, Smit MJ, Bruggeman CA, Vink C
Title
Cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines.
Journal
Reference
Authors
Couty JP, Gershengorn MC
Title
G-protein-coupled receptors encoded by human herpesviruses.
Journal
LinkDB
All DBs