KEGG   NETWORK: N00412
Entry
N00412                      Network                                
Name
HCMV UL33 to GNAI-AC-PKA signaling pathway
Definition
UL33 -> (GNAI,GNAO)
  Expanded
K22782 -> (2770,2771,2773,2775)
Class
nt06533 Chemokine signaling
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
2775  GNAO1; G protein subunit alpha o1
Perturbant
K22782 (UL33)  UL33; Cytomegalovirus G-protein coupled receptor UL33
Reference
  Authors
Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ
  Title
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.
  Journal
J Biol Chem 278:50010-23 (2003)
DOI:10.1074/jbc.M306530200
Reference
  Authors
van Cleef KW, Smit MJ, Bruggeman CA, Vink C
  Title
Cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines.
  Journal
J Clin Virol 35:343-8 (2006)
DOI:10.1016/j.jcv.2005.10.013
Reference
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
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