KEGG   NETWORK: N00479
Entry
N00479                      Network                                

Name
EBV BNLF2a to antigen processing and presentation by MHC class I molecules
Definition
BNLF2A -| TAP1/2
  Expanded
K22974 -| (6890,6891)
Class
nt06129 MHC presentation (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
6890  TAP1; transporter 1, ATP binding cassette subfamily B member
6891  TAP2; transporter 2, ATP binding cassette subfamily B member
Perturbant
K22974 (BNLF2A)  BNLF2A; EBV protein BNLF2a
Reference
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
  Authors
Horst D, van Leeuwen D, Croft NP, Garstka MA, Hislop AD, Kremmer E, Rickinson AB, Wiertz EJ, Ressing ME
  Title
Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation.
  Journal
J Immunol 182:2313-24 (2009)
DOI:10.4049/jimmunol.0803218
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