KEGG   NETWORK: N00515
Entry
N00515                      Network                                
Name
Oligoadenylate synthetase (OAS)/RNase L pathway
Definition
OAS -> 2-5A -> RNASEL
  Expanded
(4938,4939,4940) -> C20935 -> 6041
Class
nt06521 NLR signaling
nt06263 Hepatocellular carcinoma
nt06163 Hepatitis C virus (HCV)
nt06170 Influenza A virus (IAV)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Reference
Pathway
hsa04621  NOD-like receptor signaling pathway
Gene
4938  OAS1; 2'-5'-oligoadenylate synthetase 1
4939  OAS2; 2'-5'-oligoadenylate synthetase 2
4940  OAS3; 2'-5'-oligoadenylate synthetase 3
6041  RNASEL; ribonuclease L
Metabolite
C20935  2-5A
Reference
PMID:17804500
  Authors
Silverman RH
  Title
Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response.
  Journal
J Virol 81:12720-9 (2007)
DOI:10.1128/JVI.01471-07
Reference
PMID:11991644
  Authors
Han JQ, Barton DJ
  Title
Activation and evasion of the antiviral 2'-5' oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA.
  Journal
RNA 8:512-25 (2002)
DOI:10.1017/S1355838202020617
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