KEGG   NETWORK: N00516
Entry
N00516                      Network                                

Name
HCV NS3/4A to TLR3-IRF3 signaling pathway
Definition
(NS3,NS4A) -| TICAM1
  Expanded
(K22273,K22274) -| 148022
Class
nt06263 Hepatocellular carcinoma
nt06121 TLR signaling (viruses and bacteria)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
148022  TICAM1; toll like receptor adaptor molecule 1
Perturbant
K22273 (NS3)  NS3; HCV serine protease NS3
K22274 (NS4A)  NS4A; HCV non-structural protein 4A
Reference
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
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