KEGG   ORTHOLOGY: K22273
Entry
K22273            Tight     KO                                     

Name
NS3
Definition
HCV serine protease NS3 [EC:3.4.21.98]
Pathway
ko03230  Viral genome structure
ko05160  Hepatitis C
ko05203  Viral carcinogenesis
Network
nt06121  TLR signaling (viruses and bacteria)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06133  RLR signaling (viruses)
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
  Element
N00271  HCV NS3/4A to RIG-I-like receptor signaling pathway
N00516  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00517  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00522  HCV NS3 to p21-cell cycle G1/S
N00526  HCV NS3 to crosstalk between extrinsic and intrinsic apoptotic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22273  NS3; HCV serine protease NS3
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K22273  NS3; HCV serine protease NS3
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22273  NS3; HCV serine protease NS3
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22273  NS3; HCV serine protease NS3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.98  hepacivirin
     K22273  NS3; HCV serine protease NS3
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus
   K22273  NS3; HCV serine protease NS3
Genes
VP: 951475-6(NS3)
Reference
PMID:8861916
  Authors
Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z
  Title
The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.
  Journal
Cell 87:331-42 (1996)
DOI:10.1016/s0092-8674(00)81350-1
  Sequence
Reference
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
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