| Entry |
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| Name |
HCV Core to crosstalk between extrinsic and intrinsic apoptotic pathways
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| Definition |
Core -> FAS -> FADD -> CASP8 -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3 |
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| Expanded |
K22271 -> 355 -> 8772 -> 841 -> 637 -> (581,578) -> 54205 == 317 -> 842 -> 836 |
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| Class |
nt06131 Apoptosis (viruses and bacteria)
nt06263 Hepatocellular carcinoma
nt06163 Hepatitis C virus (HCV)
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| Type |
Pathogen
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| Pathway |
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| Disease |
| H00048 | Hepatocellular carcinoma |
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| Gene |
| 355 | FAS; Fas cell surface death receptor |
| 8772 | FADD; Fas associated via death domain |
| 637 | BID; BH3 interacting domain death agonist |
| 581 | BAX; BCL2 associated X, apoptosis regulator |
| 578 | BAK1; BCL2 antagonist/killer 1 |
| 54205 | CYCS; cytochrome c, somatic |
| 317 | APAF1; apoptotic peptidase activating factor 1 |
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| Perturbant |
| K22271 (Core) | Core; HCV core protein |
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| Reference |
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| Authors |
Ruggieri A, Murdolo M, Rapicetta M |
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| Title |
Induction of FAS ligand expression in a human hepatoblastoma cell line by HCV core protein. |
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| Journal |
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| Reference |
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| Authors |
Tran G. |
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| Title |
The role of hepatitis C virus in the pathogenesis of hepatocellular carcinoma |
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| Journal |
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| Reference |
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| Authors |
Fischer R, Baumert T, Blum HE |
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| Title |
Hepatitis C virus infection and apoptosis. |
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| Journal |
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| LinkDB |
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