KEGG   NETWORK: N00529
Entry
N00529                      Network                                
Name
HCV core to RXRA/PPARA-mediated transcription
Definition
Core -> (RXRA+PPARA) => (CCND1,CDK4,MYC)
  Expanded
K22271 -> (6256+5465) => (595,1019,4609)
Class
nt06263 Hepatocellular carcinoma
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
6256  RXRA; retinoid X receptor alpha
5465  PPARA; peroxisome proliferator activated receptor alpha
595  CCND1; cyclin D1
1019  CDK4; cyclin dependent kinase 4
4609  MYC; MYC proto-oncogene, bHLH transcription factor
Perturbant
K22271 (Core)  Core; HCV core protein
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
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