Entry
Name
HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
X -> BAX -> CYCS == APAF1 -> CASP9 -> CASP3
Expanded
K21854 -> 581 -> 54205 == 317 -> 842 -> 836
Class
nt06131 Apoptosis (viruses and bacteria)
nt06263 Hepatocellular carcinoma
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
Disease
H00048 Hepatocellular carcinoma
Gene
581 BAX; BCL2 associated X, apoptosis regulator
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
Perturbant
Reference
Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
Journal
Reference
Authors
Gao WY, Li D, Cai DE, Huang XY, Zheng BY, Huang YH, Chen ZX, Wang XZ
Title
Hepatitis B virus X protein sensitizes HL-7702 cells to oxidative stress-induced apoptosis through modulation of the mitochondrial permeability transition pore.
Journal
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