KEGG   NETWORK: N00534
Entry
N00534                      Network                                
Name
HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
X -> BAX -> CYCS == APAF1 -> CASP9 -> CASP3
  Expanded
K21854 -> 581 -> 54205 == 317 -> 842 -> 836
Class
nt06131 Apoptosis (viruses and bacteria)
nt06263 Hepatocellular carcinoma
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
581  BAX; BCL2 associated X, apoptosis regulator
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Perturbant
K21854 (X)  X; HBV protein X
Reference
PMID:18481805
  Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
  Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
  Journal
IUBMB Life 60:473-80 (2008)
DOI:10.1002/iub.68
Reference
PMID:27840960
  Authors
Gao WY, Li D, Cai DE, Huang XY, Zheng BY, Huang YH, Chen ZX, Wang XZ
  Title
Hepatitis B virus X protein sensitizes HL-7702 cells to oxidative stress-induced apoptosis through modulation of the mitochondrial permeability transition pore.
  Journal
Oncol Rep 37:48-56 (2017)
DOI:10.3892/or.2016.5225
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