| Entry |
|
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| Name |
GH-Jak-STAT signaling pathway
|
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| Definition |
GH -> GHR -> JAK2 -> STAT5 => IGF1 |
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| Expanded |
(2688,2689) -> 2690 -> 3717 -> (6776,6777) => 3479 |
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| Class |
|
|---|
| Type |
Reference
|
|---|
| Pathway |
| hsa04935 | Growth hormone synthesis, secretion and action |
|
|---|
| Gene |
| 2688 | GH1; growth hormone 1 |
| 2689 | GH2; growth hormone 2 |
| 2690 | GHR; growth hormone receptor |
| 3717 | JAK2; Janus kinase 2 |
| 6776 | STAT5A; signal transducer and activator of transcription 5A |
| 6777 | STAT5B; signal transducer and activator of transcription 5B |
| 3479 | IGF1; insulin like growth factor 1 |
|
|---|
| Reference |
|
|---|
| Authors |
Lu M, Flanagan JU, Langley RJ, Hay MP, Perry JK |
|---|
| Title |
Targeting growth hormone function: strategies and therapeutic applications. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Argetsinger LS, Carter-Su C |
|---|
| Title |
Mechanism of signaling by growth hormone receptor. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Dehkhoda F, Lee CMM, Medina J, Brooks AJ |
|---|
| Title |
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Carter-Su C, Rui L, Herrington J |
|---|
| Title |
Role of the tyrosine kinase JAK2 in signal transduction by growth hormone. |
|---|
| Journal |
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| LinkDB |
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