| Entry |
|
|---|
| Name |
AVP-V2R-PKA signaling pathway
|
|---|
| Definition |
AVP -> AVPR2 -> GNAS -> ADCY3/6/9 -> cAMP -> PKA -> AQP2 |
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| Expanded |
551 -> 554 -> 2778 -> (109,112,115) -> C00575 -> (5566+5567+5568) -> 359 |
|---|
| Class |
|
|---|
| Type |
Reference
|
|---|
| Pathway |
| hsa04962 | Vasopressin-regulated water reabsorption |
|
|---|
| Gene |
| 551 | AVP; arginine vasopressin |
| 554 | AVPR2; arginine vasopressin receptor 2 |
| 2778 | GNAS; GNAS complex locus |
| 109 | ADCY3; adenylate cyclase 3 |
| 112 | ADCY6; adenylate cyclase 6 |
| 115 | ADCY9; adenylate cyclase 9 |
| 5566 | PRKACA; protein kinase cAMP-activated catalytic subunit alpha |
| 5567 | PRKACB; protein kinase cAMP-activated catalytic subunit beta |
| 5568 | PRKACG; protein kinase cAMP-activated catalytic subunit gamma |
|
|---|
| Metabolite |
|
|---|
| Reference |
|
|---|
| Authors |
Boone M, Deen PM |
|---|
| Title |
Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T |
|---|
| Title |
Localization and trafficking of aquaporin 2 in the kidney. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frokiaer J, Marples D |
|---|
| Title |
Physiology and pathophysiology of renal aquaporins. |
|---|
| Journal |
J Am Soc Nephrol 10:647-63 (1999) |
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| LinkDB |
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