KEGG   NETWORK: N00928
Entry
N00928                      Network                                
Name
Escherichia NleB to TNF-NFKB signaling pathway
Definition
NleB -| GAPDH -> (RIPK1+TRAF2)
  Expanded
K23657 -| 2597 -> (8737+7186)
Class
nt06516 TNF signaling
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
2597  GAPDH; glyceraldehyde-3-phosphate dehydrogenase
8737  RIPK1; receptor interacting serine/threonine kinase 1
7186  TRAF2; TNF receptor associated factor 2
Perturbant
K23657 (NleB)  nleB; T3SS secreted effector NleB
Reference
PMID:23332158
  Authors
Gao X, Wang X, Pham TH, Feuerbacher LA, Lubos ML, Huang M, Olsen R, Mushegian A, Slawson C, Hardwidge PR
  Title
NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-kappaB activation.
  Journal
Cell Host Microbe 13:87-99 (2013)
DOI:10.1016/j.chom.2012.11.010
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