| Entry |
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| Name |
Shigella IpaB to NLRC4 Inflammasome signaling pathway
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| Definition |
IpaB -> K+ -> (NLRC4+PYCARD) -> CASP1 -> IL1B |
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| Expanded |
K13285 -> C00238 -> (58484+29108) -> 834 -> 3553 |
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| Class |
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| Type |
Pathogen
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| Pathway |
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| Disease |
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| Gene |
| 58484 | NLRC4; NLR family CARD domain containing 4 |
| 29108 | PYCARD; PYD and CARD domain containing |
| 3553 | IL1B; interleukin 1 beta |
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| Perturbant |
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| Metabolite |
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| Reference |
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| Authors |
Senerovic L, Tsunoda SP, Goosmann C, Brinkmann V, Zychlinsky A, Meissner F, Kolbe M |
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| Title |
Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages. |
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| Journal |
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| Reference |
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| Authors |
Ashida H, Mimuro H, Sasakawa C |
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| Title |
Shigella manipulates host immune responses by delivering effector proteins with specific roles. |
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| Journal |
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| LinkDB |
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