| Entry |
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| Name |
mGluR1-TRPC3 signaling pathway
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| Definition |
Glutamate -> GRM1 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -> PKC -| TRPC3 -> Ca2+ |
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| Expanded |
C00025 -> 2911 -> 2776 -> (23236,5330,5331,5332) -> C01245 -> (3708,3709,3710) -> C00076 -> (5578,5579,5582) -| 7222 -> C00076 |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 2911 | GRM1; glutamate metabotropic receptor 1 |
| 2776 | GNAQ; G protein subunit alpha q |
| 23236 | PLCB1; phospholipase C beta 1 |
| 5330 | PLCB2; phospholipase C beta 2 |
| 5331 | PLCB3; phospholipase C beta 3 |
| 5332 | PLCB4; phospholipase C beta 4 |
| 3708 | ITPR1; inositol 1,4,5-trisphosphate receptor type 1 |
| 3709 | ITPR2; inositol 1,4,5-trisphosphate receptor type 2 |
| 3710 | ITPR3; inositol 1,4,5-trisphosphate receptor type 3 |
| 5578 | PRKCA; protein kinase C alpha |
| 5579 | PRKCB; protein kinase C beta |
| 5582 | PRKCG; protein kinase C gamma |
| 7222 | TRPC3; transient receptor potential cation channel subfamily C member 3 |
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| Metabolite |
| C01245 | D-myo-Inositol 1,4,5-trisphosphate |
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| Reference |
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| Authors |
Kano M, Watanabe T |
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| Title |
Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease. |
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| Journal |
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| Reference |
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| Authors |
Becker EB |
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| Title |
The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia. |
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| Journal |
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| Reference |
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| Authors |
Venkatachalam K, Zheng F, Gill DL |
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| Title |
Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. |
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| Journal |
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| Reference |
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| Authors |
Trebak M, Hempel N, Wedel BJ, Smyth JT, Bird GS, Putney JW Jr |
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| Title |
Negative regulation of TRPC3 channels by protein kinase C-mediated phosphorylation of serine 712. |
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| Journal |
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| LinkDB |
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