KEGG   NETWORK: N00986
Entry
N00986                      Network                                
Name
Mutation-caused aberrant Htt to VGCC-Ca2+ -apoptotic pathway
Definition
HTT* -| STX1A -| VGCC(N-type) -> Ca2+
  Expanded
3064v1 -| 6804 -| 774 -> C00076
Class
nt06461 Huntington disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05016  Huntington disease
Disease
H00059  Huntington disease
Gene
3064  HTT; huntingtin
6804  STX1A; syntaxin 1A
774  CACNA1B; calcium voltage-gated channel subunit alpha1 B
Variant
3064v1 (HTT*)  HTT mutation
Metabolite
C00076  Calcium cation
Reference
PMID:16162412
  Authors
Swayne LA, Chen L, Hameed S, Barr W, Charlesworth E, Colicos MA, Zamponi GW, Braun JE
  Title
Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels.
  Journal
Mol Cell Neurosci 30:339-51 (2005)
DOI:10.1016/j.mcn.2005.07.016
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