Entry |
|
Name |
Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway
|
Definition |
APP* -> Abeta -> PPID -> MPTP -> CYCS |
Expanded |
351v1 -> (C16515,C16514) -> 5481 -> (7416,7417,7419,291,292,293,83447) -> 54205 |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
351 | APP; amyloid beta precursor protein |
5481 | PPID; peptidylprolyl isomerase D |
7416 | VDAC1; voltage dependent anion channel 1 |
7417 | VDAC2; voltage dependent anion channel 2 |
7419 | VDAC3; voltage dependent anion channel 3 |
291 | SLC25A4; solute carrier family 25 member 4 |
292 | SLC25A5; solute carrier family 25 member 5 |
293 | SLC25A6; solute carrier family 25 member 6 |
83447 | SLC25A31; solute carrier family 25 member 31 |
54205 | CYCS; cytochrome c, somatic |
|
Variant |
351v1 (APP*) APP mutation
|
Metabolite |
C16515 | Beta-amyloid protein 42 |
C16514 | Beta-amyloid protein 40 |
|
Reference |
|
Authors |
Pajak B, Kania E, Orzechowski A |
Title |
Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's Disease. |
Journal |
|
Reference |
|
Authors |
Tan Y, Deng Y, Qing H |
Title |
Calcium channel blockers and Alzheimer's disease. |
Journal |
|
Reference |
|
Authors |
Du H, Yan SS |
Title |
Mitochondrial permeability transition pore in Alzheimer's disease: cyclophilin D and amyloid beta. |
Journal |
|
LinkDB |
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