KEGG   NETWORK: N01011
Entry
N01011                      Network                                
Name
IRE1a-XBP1 signaling pathway
Definition
ERN1 -> XBP1 => DDIT3
  Expanded
2081 -> 7494 => 1649
Class
nt06534 Unfolded protein response
nt06460 Alzheimer disease
nt06463 Parkinson disease
nt06464 Amyotrophic lateral sclerosis
nt06466 Pathways of neurodegeneration
Type
Reference
Pathway
hsa04141  Protein processing in endoplasmic reticulum
Gene
2081  ERN1; endoplasmic reticulum to nucleus signaling 1
7494  XBP1; X-box binding protein 1
1649  DDIT3; DNA damage inducible transcript 3
Reference
  Authors
Walter P, Ron D
  Title
The unfolded protein response: from stress pathway to homeostatic regulation.
  Journal
Science 334:1081-6 (2011)
DOI:10.1126/science.1209038
Reference
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
  Authors
Deldicque L
  Title
Endoplasmic reticulum stress in human skeletal muscle: any contribution to sarcopenia?
  Journal
Front Physiol 4:236 (2013)
DOI:10.3389/fphys.2013.00236
Reference
  Authors
Basseri S, Austin RC
  Title
Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential.
  Journal
Biochem Res Int 2012:841362 (2012)
DOI:10.1155/2012/841362
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