Entry Name Shigella IpgB1 to ITGA/B-FAK-RAC signaling pathway
Definition IpgB1 -> RAC1
Expanded K13742 -> 5879
Class nt06135 Cytoskeletal regulation (viruses and bacteria)
Type Pathogen
Pathway Disease Gene 5879 RAC1; Rac family small GTPase 1
Perturbant K13742 (IpgB1) ipgB1; protein IpgB1
Reference Authors Ohya K, Handa Y, Ogawa M, Suzuki M, Sasakawa C
Title IpgB1 is a novel Shigella effector protein involved in bacterial invasion of host cells. Its activity to promote membrane ruffling via Rac1 and Cdc42 activation.
Journal Reference Authors Huang Z, Sutton SE, Wallenfang AJ, Orchard RC, Wu X, Feng Y, Chai J, Alto NM
Title Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics.
Journal LinkDB All DBs
