Entry Name Escherichia EspM to LPA-GNA12/13-Rho signaling pathway
Definition EspM -> RHOA -> ROCK1/2
Expanded K23653 -> 387 -> (6093,9475)
Class nt06180 Pathogenic Escherichia coli
Type Pathogen
Pathway hsa05130 Pathogenic Escherichia coli infection
Disease H00277 Enterohemorrhagic Escherichia coli (EHEC) infection
H00278 Enteropathogenic Escherichia coli (EPEC) infection
Gene 387 RHOA; ras homolog family member A
6093 ROCK1; Rho associated coiled-coil containing protein kinase 1
9475 ROCK2; Rho associated coiled-coil containing protein kinase 2
Perturbant K23653 (EspM) espM; T3SS effector EspM
Reference Authors Simovitch M, Sason H, Cohen S, Zahavi EE, Melamed-Book N, Weiss A, Aroeti B, Rosenshine I
Title EspM inhibits pedestal formation by enterohaemorrhagic Escherichia coli and enteropathogenic E. coli and disrupts the architecture of a polarized epithelial monolayer.
Journal Reference Authors Arbeloa A, Garnett J, Lillington J, Bulgin RR, Berger CN, Lea SM, Matthews S, Frankel G
Title EspM2 is a RhoA guanine nucleotide exchange factor.
Journal LinkDB All DBs
