KEGG   NETWORK: N01089
Entry
N01089                      Network                                

Name
Escherichia EspM to LPA-GNA12/13-Rho signaling pathway
Definition
EspM -> RHOA -> ROCK1/2
  Expanded
K23653 -> 387 -> (6093,9475)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
387  RHOA; ras homolog family member A
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2
Perturbant
K23653 (EspM)  espM; T3SS effector EspM
Reference
  Authors
Simovitch M, Sason H, Cohen S, Zahavi EE, Melamed-Book N, Weiss A, Aroeti B, Rosenshine I
  Title
EspM inhibits pedestal formation by enterohaemorrhagic Escherichia coli and enteropathogenic E. coli and disrupts the architecture of a polarized epithelial  monolayer.
  Journal
Cell Microbiol 12:489-505 (2010)
DOI:10.1111/j.1462-5822.2009.01410.x
Reference
  Authors
Arbeloa A, Garnett J, Lillington J, Bulgin RR, Berger CN, Lea SM, Matthews S, Frankel G
  Title
EspM2 is a RhoA guanine nucleotide exchange factor.
  Journal
Cell Microbiol 12:654-64 (2010)
DOI:10.1111/j.1462-5822.2009.01423.x
LinkDB

DBGET integrated database retrieval system