Entry Name Escherichia EspM to LPA-GNA12/13-Rho signaling pathway
Definition EspM -> RHOA -> ROCK1/2
Expanded K23653 -> 387 -> (6093,9475)
Class nt06135 Cytoskeletal regulation (viruses and bacteria)
Type Pathogen
Pathway hsa05130 Pathogenic Escherichia coli infection
Disease H00277 Enterohemorrhagic Escherichia coli (EHEC) infection
H00278 Enteropathogenic Escherichia coli (EPEC) infection
Gene 387 RHOA; ras homolog family member A
6093 ROCK1; Rho associated coiled-coil containing protein kinase 1
9475 ROCK2; Rho associated coiled-coil containing protein kinase 2
Perturbant K23653 (EspM) espM; T3SS effector EspM
Reference Authors Simovitch M, Sason H, Cohen S, Zahavi EE, Melamed-Book N, Weiss A, Aroeti B, Rosenshine I
Title EspM inhibits pedestal formation by enterohaemorrhagic Escherichia coli and enteropathogenic E. coli and disrupts the architecture of a polarized epithelial monolayer.
Journal Reference Authors Arbeloa A, Garnett J, Lillington J, Bulgin RR, Berger CN, Lea SM, Matthews S, Frankel G
Title EspM2 is a RhoA guanine nucleotide exchange factor.
Journal LinkDB All DBs
