KEGG   NETWORK: N01150
Entry
N01150                      Network                                
Name
Mutation-inactivated VAPB to ATF6-mediated transcription
Definition
VAPB* -| ATF6
  Expanded
9217v1 -| 22926
Class
nt06534 Unfolded protein response
nt06464 Amyotrophic lateral sclerosis
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05014  Amyotrophic lateral sclerosis
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Gene
9217  VAPB; VAMP associated protein B and C
22926  ATF6; activating transcription factor 6
Variant
9217v1 (VAPB*)  VAPB mutation
Reference
  Authors
Gkogkas C, Middleton S, Kremer AM, Wardrope C, Hannah M, Gillingwater TH, Skehel P
  Title
VAPB interacts with and modulates the activity of ATF6.
  Journal
Hum Mol Genet 17:1517-26 (2008)
DOI:10.1093/hmg/ddn040
Reference
  Authors
Kanekura K, Nishimoto I, Aiso S, Matsuoka M
  Title
Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).
  Journal
J Biol Chem 281:30223-33 (2006)
DOI:10.1074/jbc.M605049200
Reference
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
  Authors
Webster CP, Smith EF, Shaw PJ, De Vos KJ
  Title
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
  Journal
Front Mol Neurosci 10:123 (2017)
DOI:10.3389/fnmol.2017.00123
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