KEGG   NETWORK: N01306
Entry
N01306                      Network                                

Name
AngII-AT1R-NOX2 signaling pathway
Definition
AngII -> AGTR1 -> NOX2 -> ROS -> NFKB -> (VCAM1,IL6,MMP2,MMP9)
  Expanded
C02135 -> 185 -> 1536 -> (C00704+C00027) -> (4790+5970) -> (7412,3569,4313,4318)
Class
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Reference
Gene
185  AGTR1; angiotensin II receptor type 1
1536  CYBB; cytochrome b-245 beta chain
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
7412  VCAM1; vascular cell adhesion molecule 1
3569  IL6; interleukin 6
4313  MMP2; matrix metallopeptidase 2
4318  MMP9; matrix metallopeptidase 9
Metabolite
C02135  Angiotensin II
C00704  Superoxide
C00027  Hydrogen peroxide
Reference
  Authors
Nguyen Dinh Cat A, Montezano AC, Burger D, Touyz RM
  Title
Angiotensin II, NADPH oxidase, and redox signaling in the vasculature.
  Journal
Antioxid Redox Signal 19:1110-20 (2013)
DOI:10.1089/ars.2012.4641
Reference
  Authors
Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R, Eguchi S
  Title
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.
  Journal
Physiol Rev 98:1627-1738 (2018)
DOI:10.1152/physrev.00038.2017
Reference
  Authors
Harrison DG, Cai H, Landmesser U, Griendling KK
  Title
Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease.
  Journal
J Renin Angiotensin Aldosterone Syst 4:51-61 (2003)
DOI:10.3317/jraas.2003.014
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