Homo sapiens (human): 4318
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Entry
4318 CDS
T01001
Symbol
MMP9, CLG4B, GELB, MANDP2, MMP-9
Name
(RefSeq) matrix metallopeptidase 9
KO
K01403
matrix metalloproteinase-9 (gelatinase B) [EC:
3.4.24.35
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01522
Endocrine resistance
hsa04657
IL-17 signaling pathway
hsa04668
TNF signaling pathway
hsa04670
Leukocyte transendothelial migration
hsa04915
Estrogen signaling pathway
hsa04926
Relaxin signaling pathway
hsa05161
Hepatitis B
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05215
Prostate cancer
hsa05219
Bladder cancer
hsa05415
Diabetic cardiomyopathy
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06162
Hepatitis B virus (HBV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06240
Transcription (cancer)
nt06263
Hepatocellular carcinoma
nt06272
Prostate cancer
Element
N00128
TMPRSS2-ERG fusion to transcriptional activation
N00130
TMPRSS2-ETV5 fusion to transcriptional activation
N00545
HBV HBx to ERK signaling pathway
N01306
AngII-AT1R-NOX2 signaling pathway
Disease
H00025
Penile cancer
H00479
Metaphyseal dysplasias
Drug target
Andecaliximab:
D11262
Batimastat:
D03061
Cipemastat:
D03517
Ilomastat:
D03793
Marimastat:
D03795
Prinomastat:
D03797
Rebimastat:
D03800
Tanomastat:
D03802
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
4318 (MMP9)
09150 Organismal Systems
09151 Immune system
04657 IL-17 signaling pathway
4318 (MMP9)
04670 Leukocyte transendothelial migration
4318 (MMP9)
09152 Endocrine system
04915 Estrogen signaling pathway
4318 (MMP9)
04926 Relaxin signaling pathway
4318 (MMP9)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4318 (MMP9)
05202 Transcriptional misregulation in cancer
4318 (MMP9)
05206 MicroRNAs in cancer
4318 (MMP9)
05205 Proteoglycans in cancer
4318 (MMP9)
09162 Cancer: specific types
05219 Bladder cancer
4318 (MMP9)
05215 Prostate cancer
4318 (MMP9)
09172 Infectious disease: viral
05161 Hepatitis B
4318 (MMP9)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
4318 (MMP9)
05418 Fluid shear stress and atherosclerosis
4318 (MMP9)
05415 Diabetic cardiomyopathy
4318 (MMP9)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
4318 (MMP9)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
4318 (MMP9)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.24 Metalloendopeptidases
3.4.24.35 gelatinase B
4318 (MMP9)
Peptidases and inhibitors [BR:
hsa01002
]
Metallo peptidases
Family M10
4318 (MMP9)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_M10
fn2
Hemopexin
PT
PG_binding_1
Reprolysin_3
Reprolysin_4
DUF4953
Peptidase_M66
Motif
Other DBs
NCBI-GeneID:
4318
NCBI-ProteinID:
NP_004985
OMIM:
120361
HGNC:
7176
Ensembl:
ENSG00000100985
UniProt:
P14780
Structure
PDB
PDBj
LinkDB
All DBs
Position
20:46008908..46016561
Genome browser
AA seq
707 aa
AA seq
DB search
MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP
FDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRS
YSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYS
ACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYST
CTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMY
PMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSER
PTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYW
RFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRR
LDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLD
THDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
NT seq
2124 nt
NT seq
+upstream
nt +downstream
nt
atgagcctctggcagcccctggtcctggtgctcctggtgctgggctgctgctttgctgcc
cccagacagcgccagtccacccttgtgctcttccctggagacctgagaaccaatctcacc
gacaggcagctggcagaggaatacctgtaccgctatggttacactcgggtggcagagatg
cgtggagagtcgaaatctctggggcctgcgctgctgcttctccagaagcaactgtccctg
cccgagaccggtgagctggatagcgccacgctgaaggccatgcgaaccccacggtgcggg
gtcccagacctgggcagattccaaacctttgagggcgacctcaagtggcaccaccacaac
atcacctattggatccaaaactactcggaagacttgccgcgggcggtgattgacgacgcc
tttgcccgcgccttcgcactgtggagcgcggtgacgccgctcaccttcactcgcgtgtac
agccgggacgcagacatcgtcatccagtttggtgtcgcggagcacggagacgggtatccc
ttcgacgggaaggacgggctcctggcacacgcctttcctcctggccccggcattcaggga
gacgcccatttcgacgatgacgagttgtggtccctgggcaagggcgtcgtggttccaact
cggtttggaaacgcagatggcgcggcctgccacttccccttcatcttcgagggccgctcc
tactctgcctgcaccaccgacggtcgctccgacggcttgccctggtgcagtaccacggcc
aactacgacaccgacgaccggtttggcttctgccccagcgagagactctacacccaggac
ggcaatgctgatgggaaaccctgccagtttccattcatcttccaaggccaatcctactcc
gcctgcaccacggacggtcgctccgacggctaccgctggtgcgccaccaccgccaactac
gaccgggacaagctcttcggcttctgcccgacccgagctgactcgacggtgatggggggc
aactcggcgggggagctgtgcgtcttccccttcactttcctgggtaaggagtactcgacc
tgtaccagcgagggccgcggagatgggcgcctctggtgcgctaccacctcgaactttgac
agcgacaagaagtggggcttctgcccggaccaaggatacagtttgttcctcgtggcggcg
catgagttcggccacgcgctgggcttagatcattcctcagtgccggaggcgctcatgtac
cctatgtaccgcttcactgaggggccccccttgcataaggacgacgtgaatggcatccgg
cacctctatggtcctcgccctgaacctgagccacggcctccaaccaccaccacaccgcag
cccacggctcccccgacggtctgccccaccggaccccccactgtccacccctcagagcgc
cccacagctggccccacaggtcccccctcagctggccccacaggtccccccactgctggc
ccttctacggccactactgtgcctttgagtccggtggacgatgcctgcaacgtgaacatc
ttcgacgccatcgcggagattgggaaccagctgtatttgttcaaggatgggaagtactgg
cgattctctgagggcagggggagccggccgcagggccccttccttatcgccgacaagtgg
cccgcgctgccccgcaagctggactcggtctttgaggagcggctctccaagaagcttttc
ttcttctctgggcgccaggtgtgggtgtacacaggcgcgtcggtgctgggcccgaggcgt
ctggacaagctgggcctgggagccgacgtggcccaggtgaccggggccctccggagtggc
agggggaagatgctgctgttcagcgggcggcgcctctggaggttcgacgtgaaggcgcag
atggtggatccccggagcgccagcgaggtggaccggatgttccccggggtgcctttggac
acgcacgacgtcttccagtaccgagagaaagcctatttctgccaggaccgcttctactgg
cgcgtgagttcccggagtgagttgaaccaggtggaccaagtgggctacgtgacctatgac
atcctgcagtgccctgaggactag
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