KEGG   NETWORK: N01315
Entry
N01315                      Network                                

Name
Lectin pathway of coagulation activation
Definition
(MBL2+MASP1/2) -> F2 -- FG -> Fibrin
  Expanded
(4153+(5648,10747)) -> 2147 -- (2243+2244+2266) -> C00290
Class
nt06136 Complement activation (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Reference
Pathway
hsa04610  Complement and coagulation cascades
Gene
4153  MBL2; mannose binding lectin 2
5648  MASP1; mannan binding lectin serine peptidase 1
10747  MASP2; mannan binding lectin serine peptidase 2
2147  F2; coagulation factor II, thrombin
2243  FGA; fibrinogen alpha chain
2244  FGB; fibrinogen beta chain
2266  FGG; fibrinogen gamma chain
Metabolite
C00290  Fibrin
Reference
  Authors
Krarup A, Wallis R, Presanis JS, Gal P, Sim RB
  Title
Simultaneous activation of complement and coagulation by MBL-associated serine protease 2.
  Journal
PLoS One 2:e623 (2007)
DOI:10.1371/journal.pone.0000623
Reference
  Authors
Wiegner R, Chakraborty S, Huber-Lang M
  Title
Complement-coagulation crosstalk on cellular and artificial surfaces.
  Journal
Immunobiology 221:1073-9 (2016)
DOI:10.1016/j.imbio.2016.06.005
Reference
  Authors
Hess K, Ajjan R, Phoenix F, Dobo J, Gal P, Schroeder V
  Title
Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation.
  Journal
PLoS One 7:e35690 (2012)
DOI:10.1371/journal.pone.0035690
Reference
  Authors
Gulla KC, Gupta K, Krarup A, Gal P, Schwaeble WJ, Sim RB, O'Connor CD, Hajela K
  Title
Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot.
  Journal
Immunology 129:482-95 (2010)
DOI:10.1111/j.1365-2567.2009.03200.x
LinkDB

DBGET integrated database retrieval system