KEGG   NETWORK: N01319
Entry
N01319                      Network                                

Name
SARS-CoV-2 nsp6 and ORF6 to RIG-I-IRF7/3 signaling pathway
Definition
(nsp6,ORF6) -| IRF3
  Expanded
(K25016,K24580) -| 3661
Class
nt06133 RLR signaling (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Pathogen
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
3661  IRF3; interferon regulatory factor 3
Perturbant
K25016 (nsp6)  nsp6; SARS coronavirus non-structural protein 6
K24580 (ORF6)  6; SARS coronavirus accessory protein 6
Reference
  Authors
Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY
  Title
Evasion of Type I Interferon by SARS-CoV-2.
  Journal
Cell Rep 33:108234 (2020)
DOI:10.1016/j.celrep.2020.108234
Reference
  Authors
Harrison AG, Lin T, Wang P
  Title
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis.
  Journal
Trends Immunol S1471-4906(20)30233-7 (2020)
DOI:10.1016/j.it.2020.10.004
Reference
  Authors
Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z, Xiang Z, Wang J
  Title
Activation and evasion of type I interferon responses by SARS-CoV-2.
  Journal
Nat Commun 11:3810 (2020)
DOI:10.1038/s41467-020-17665-9
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