Homo sapiens (human): 3661
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Entry
3661 CDS
T01001
Symbol
IRF3, IIAE7
Name
(RefSeq) interferon regulatory factor 3
KO
K05411
interferon regulatory factor 3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04936
Alcoholic liver disease
hsa05131
Shigellosis
hsa05133
Pertussis
hsa05135
Yersinia infection
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05203
Viral carcinogenesis
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06182
Shigella
nt06263
Hepatocellular carcinoma
nt06517
TLR signaling
nt06519
RLR signaling
nt06520
CGAS-STING signaling
Element
N00149
TLR3-IRF3 signaling pathway
N00161
KSHV vIRF1/2 to TLR3-IRF3 signaling pathway
N00346
HPV E6 to TLR-IRF3 signaling pathway
N00395
cGAS-STING signaling pathway
N00440
HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway
N00469
RIG-I-IRF7/3 signaling pathway
N00470
EBV BGLF4 to RIG-I-like receptor signaling pathway
N00517
HCV NS3/4A to TLR3-IRF3 signaling pathway
N00553
TLR4-IRF3/7 signaling pathway
N00568
HSV US3 to IRF3 signaling pathway
N00686
MV N to RIG-I-IRF7/3 signaling pathway
N00687
MV V/C to RIG-I-IRF7/3 signaling pathway
N00729
IAV NS1 to RIG-I-like receptor signaling pathway
N01308
MDA5-IRF7/3 signaling pathway
N01319
SARS-CoV-2 nsp6 and ORF6 to RIG-I-IRF7/3 signaling pathway
N01320
SARS-CoV-2 nsp3 to RIG-I-IRF7/3 signaling pathway
Disease
H02536
Infection-induced acute encephalopathy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3661 (IRF3)
04621 NOD-like receptor signaling pathway
3661 (IRF3)
04622 RIG-I-like receptor signaling pathway
3661 (IRF3)
04623 Cytosolic DNA-sensing pathway
3661 (IRF3)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
3661 (IRF3)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
3661 (IRF3)
05161 Hepatitis B
3661 (IRF3)
05160 Hepatitis C
3661 (IRF3)
05171 Coronavirus disease - COVID-19
3661 (IRF3)
05164 Influenza A
3661 (IRF3)
05162 Measles
3661 (IRF3)
05168 Herpes simplex virus 1 infection
3661 (IRF3)
05163 Human cytomegalovirus infection
3661 (IRF3)
05167 Kaposi sarcoma-associated herpesvirus infection
3661 (IRF3)
05169 Epstein-Barr virus infection
3661 (IRF3)
05165 Human papillomavirus infection
3661 (IRF3)
09171 Infectious disease: bacterial
05131 Shigellosis
3661 (IRF3)
05135 Yersinia infection
3661 (IRF3)
05133 Pertussis
3661 (IRF3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3661 (IRF3)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
3661 (IRF3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
3661 (IRF3)
04131 Membrane trafficking [BR:
hsa04131
]
3661 (IRF3)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Helix-turn-helix
Tryptophan clusters interferon-regulating factors
3661 (IRF3)
Membrane trafficking [BR:
hsa04131
]
Autophagy
Other autophagy associated proteins
TRIM-directed selective autophagy
3661 (IRF3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IRF-3
IRF
Motif
Other DBs
NCBI-GeneID:
3661
NCBI-ProteinID:
NP_001562
OMIM:
603734
HGNC:
6118
Ensembl:
ENSG00000126456
UniProt:
Q14653
Structure
PDB
PDBj
LinkDB
All DBs
Position
19:complement(49659572..49665857)
Genome browser
AA seq
427 aa
AA seq
DB search
MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA
TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP
DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT
PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG
WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL
PNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTK
RLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMD
FQGPGES
NT seq
1284 nt
NT seq
+upstream
nt +downstream
nt
atgggaaccccaaagccacggatcctgccctggctggtgtcgcagctggacctggggcaa
ctggagggcgtggcctgggtgaacaagagccgcacgcgcttccgcatcccttggaagcac
ggcctacggcaggatgcacagcaggaggatttcggaatcttccaggcctgggccgaggcc
actggtgcatatgttcccgggagggataagccagacctgccaacctggaagaggaatttc
cgctctgccctcaaccgcaaagaagggttgcgtttagcagaggaccggagcaaggaccct
cacgacccacataaaatctacgagtttgtgaactcaggagttggggacttttcccagcca
gacacctctccggacaccaatggtggaggcagtacttctgatacccaggaagacattctg
gatgagttactgggtaacatggtgttggccccactcccagatccgggacccccaagcctg
gctgtagcccctgagccctgccctcagcccctgcggagccccagcttggacaatcccact
cccttcccaaacctggggccctctgagaacccactgaagcggctgttggtgccgggggaa
gagtgggagttcgaggtgacagccttctaccggggccgccaagtcttccagcagaccatc
tcctgcccggagggcctgcggctggtggggtccgaagtgggagacaggacgctgcctgga
tggccagtcacactgccagaccctggcatgtccctgacagacaggggagtgatgagctac
gtgaggcatgtgctgagctgcctgggtgggggactggctctctggcgggccgggcagtgg
ctctgggcccagcggctggggcactgccacacatactgggcagtgagcgaggagctgctc
cccaacagcgggcatgggcctgatggcgaggtccccaaggacaaggaaggaggcgtgttt
gacctggggcccttcattgtagatctgattaccttcacggaaggaagcggacgctcacca
cgctatgccctctggttctgtgtgggggagtcatggccccaggaccagccgtggaccaag
aggctcgtgatggtcaaggttgtgcccacgtgcctcagggccttggtagaaatggcccgg
gtagggggtgcctcctccctggagaatactgtggacctgcacatttccaacagccaccca
ctctccctcacctccgaccagtacaaggcctacctgcaggacttggtggagggcatggat
ttccagggccctggggagagctga
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