| Entry |
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| Symbol |
IRF3, IIAE7
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| Name |
(RefSeq) interferon regulatory factor 3
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| KO |
| K05411 | interferon regulatory factor 3 |
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| Organism |
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| Pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05163 | Human cytomegalovirus infection |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
| hsa05168 | Herpes simplex virus 1 infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
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| Network |
nt06121 TLR signaling (viruses and bacteria) nt06133 RLR signaling (viruses) nt06134 CGAS-STING signaling (viruses and bacteria) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06166 Human papillomavirus (HPV) nt06167 Human cytomegalovirus (HCMV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06170 Influenza A virus (IAV) nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nt06221 TLR signaling nt06263 Hepatocellular carcinoma |
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| Element |
| N00149 | TLR3-IRF3 signaling pathway |
| N00161 | KSHV vIRF1/2 to TLR3-IRF3 signaling pathway |
| N00346 | HPV E6 to TLR-IRF3 signaling pathway |
| N00395 | cGAS-STING signaling pathway |
| N00440 | HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway |
| N00469 | RIG-I-IRF7/3 signaling pathway |
| N00470 | EBV BGLF4 to RIG-I-like receptor signaling pathway |
| N00517 | HCV NS3/4A to TLR3-IRF3 signaling pathway |
| N00553 | TLR4-IRF3/7 signaling pathway |
| N00568 | HSV US3 to IRF3 signaling pathway |
| N00686 | MV N to RIG-I-IRF7/3 signaling pathway |
| N00687 | MV V/C to RIG-I-IRF7/3 signaling pathway |
| N00729 | IAV NS1 to RIG-I-like receptor signaling pathway |
| N01308 | MDA5-IRF7/3 signaling pathway |
| N01319 | SARS-CoV-2 nsp6 and ORF6 to RIG-I-IRF7/3 signaling pathway |
| N01320 | SARS-CoV-2 nsp3 to RIG-I-IRF7/3 signaling pathway |
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| Disease |
| H02536 | Infection-induced acute encephalopathy |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3661 (IRF3)
04621 NOD-like receptor signaling pathway
3661 (IRF3)
04622 RIG-I-like receptor signaling pathway
3661 (IRF3)
04623 Cytosolic DNA-sensing pathway
3661 (IRF3)
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
3661 (IRF3)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
3661 (IRF3)
05161 Hepatitis B
3661 (IRF3)
05160 Hepatitis C
3661 (IRF3)
05171 Coronavirus disease - COVID-19
3661 (IRF3)
05164 Influenza A
3661 (IRF3)
05162 Measles
3661 (IRF3)
05168 Herpes simplex virus 1 infection
3661 (IRF3)
05163 Human cytomegalovirus infection
3661 (IRF3)
05167 Kaposi sarcoma-associated herpesvirus infection
3661 (IRF3)
05169 Epstein-Barr virus infection
3661 (IRF3)
05165 Human papillomavirus infection
3661 (IRF3)
09171 Infectious disease: bacterial
05131 Shigellosis
3661 (IRF3)
05135 Yersinia infection
3661 (IRF3)
05133 Pertussis
3661 (IRF3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3661 (IRF3)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
3661 (IRF3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:hsa03000]
3661 (IRF3)
04131 Membrane trafficking [BR:hsa04131]
3661 (IRF3)
Transcription factors [BR:hsa03000]
Eukaryotic type
Helix-turn-helix
Tryptophan clusters interferon-regulating factors
3661 (IRF3)
Membrane trafficking [BR:hsa04131]
Autophagy
Other autophagy associated proteins
TRIM-directed selective autophagy
3661 (IRF3)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
19:complement(49659572..49665857)
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| AA seq |
427 aa
MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA
TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP
DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT
PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG
WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL
PNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTK
RLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMD
FQGPGES |
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| NT seq |
1284 nt +upstreamnt +downstreamnt
atgggaaccccaaagccacggatcctgccctggctggtgtcgcagctggacctggggcaa
ctggagggcgtggcctgggtgaacaagagccgcacgcgcttccgcatcccttggaagcac
ggcctacggcaggatgcacagcaggaggatttcggaatcttccaggcctgggccgaggcc
actggtgcatatgttcccgggagggataagccagacctgccaacctggaagaggaatttc
cgctctgccctcaaccgcaaagaagggttgcgtttagcagaggaccggagcaaggaccct
cacgacccacataaaatctacgagtttgtgaactcaggagttggggacttttcccagcca
gacacctctccggacaccaatggtggaggcagtacttctgatacccaggaagacattctg
gatgagttactgggtaacatggtgttggccccactcccagatccgggacccccaagcctg
gctgtagcccctgagccctgccctcagcccctgcggagccccagcttggacaatcccact
cccttcccaaacctggggccctctgagaacccactgaagcggctgttggtgccgggggaa
gagtgggagttcgaggtgacagccttctaccggggccgccaagtcttccagcagaccatc
tcctgcccggagggcctgcggctggtggggtccgaagtgggagacaggacgctgcctgga
tggccagtcacactgccagaccctggcatgtccctgacagacaggggagtgatgagctac
gtgaggcatgtgctgagctgcctgggtgggggactggctctctggcgggccgggcagtgg
ctctgggcccagcggctggggcactgccacacatactgggcagtgagcgaggagctgctc
cccaacagcgggcatgggcctgatggcgaggtccccaaggacaaggaaggaggcgtgttt
gacctggggcccttcattgtagatctgattaccttcacggaaggaagcggacgctcacca
cgctatgccctctggttctgtgtgggggagtcatggccccaggaccagccgtggaccaag
aggctcgtgatggtcaaggttgtgcccacgtgcctcagggccttggtagaaatggcccgg
gtagggggtgcctcctccctggagaatactgtggacctgcacatttccaacagccaccca
ctctccctcacctccgaccagtacaaggcctacctgcaggacttggtggagggcatggat
ttccagggccctggggagagctga |
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