KEGG   NETWORK: N01320
Entry
N01320                      Network                                

Name
SARS-CoV-2 nsp3 to RIG-I-IRF7/3 signaling pathway
Definition
nsp3 -| ISG15 -- IRF3
  Expanded
K25013 -| 9636 -- 3661
Class
nt06133 RLR signaling (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Variant
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
9636  ISG15; ISG15 ubiquitin like modifier
3661  IRF3; interferon regulatory factor 3
Perturbant
K25013 (nsp3)  nsp3; SARS coronavirus non-structural protein 3
Reference
  Authors
McClain CB, Vabret N
  Title
SARS-CoV-2: the many pros of targeting PLpro.
  Journal
Signal Transduct Target Ther 5:223 (2020)
DOI:10.1038/s41392-020-00335-z
Reference
  Authors
Stancioiu F, Papadakis GZ, Kteniadakis S, Izotov BN, Coleman MD, Spandidos DA, Tsatsakis A
  Title
A dissection of SARSCoV2 with clinical implications (Review).
  Journal
Int J Mol Med 46:489-508 (2020)
DOI:10.3892/ijmm.2020.4636
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