KEGG   NETWORK: N01336
Entry
N01336                      Network                                
Name
CHRNA7-E2F signaling pathway
Definition
ACh -> CHRNA7 -> ARRB1 -> SRC -> RAF1 -> RB1 // E2F1
  Expanded
C01996 -> 1139 -> 408 -> 6714 -> 5894 -> 5925 // 1869
Class
nt06230 Cell cycle
Type
Reference
Gene
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
408  ARRB1; arrestin beta 1
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
Metabolite
C01996  Acetylcholine
Reference
  Authors
Resende RR, Adhikari A
  Title
Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation.
  Journal
Cell Commun Signal 7:20 (2009)
DOI:10.1186/1478-811X-7-20
Reference
  Authors
Dasgupta P, Rastogi S, Pillai S, Ordonez-Ercan D, Morris M, Haura E, Chellappan S
  Title
Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways.
  Journal
J Clin Invest 116:2208-2217 (2006)
DOI:10.1172/JCI28164
Reference
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
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