KEGG   NETWORK: N01341
Entry
N01341                      Network                                

Name
NNK/NNN to Jak-STAT signaling pathway
Definition
(NNK,NNN) -> CHRNA7 -> JAK2 -> STAT3 => IKBKE
  Expanded
(C16453,C16452) -> 1139 -> 3717 -> 6774 => 9641
Class
nt06219 JAK-STAT signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00014  Non-small cell lung cancer
Gene
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
3717  JAK2; Janus kinase 2
6774  STAT3; signal transducer and activator of transcription 3
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
Perturbant
C16453 (NNK)  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16452 (NNN)  N'-Nitrosonornicotine
Reference
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
  Authors
Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ
  Title
IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.
  Journal
Oncogene 32:151-9 (2013)
DOI:10.1038/onc.2012.39
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