| Entry |
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| Name |
NNK/NNN to Jak-STAT signaling pathway
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| Definition |
(NNK,NNN) -> CHRNA7 -> JAK2 -> STAT3 => IKBKE |
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| Expanded |
(C16453,C16452) -> 1139 -> 3717 -> 6774 => 9641 |
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| Class |
nt06219 JAK-STAT signaling (cancer)
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| Type |
Env factor
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| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
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| Disease |
| H00014 | Non-small cell lung cancer |
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| Gene |
| 1139 | CHRNA7; cholinergic receptor nicotinic alpha 7 subunit |
| 3717 | JAK2; Janus kinase 2 |
| 6774 | STAT3; signal transducer and activator of transcription 3 |
| 9641 | IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon |
|
|---|
| Perturbant |
| C16453 (NNK) | 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone |
| C16452 (NNN) | N'-Nitrosonornicotine |
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| Reference |
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| Authors |
Grando SA |
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| Title |
Connections of nicotine to cancer. |
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| Journal |
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| Reference |
|
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| Authors |
Schaal C, Chellappan SP |
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| Title |
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. |
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| Journal |
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| Reference |
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| Authors |
Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ |
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| Title |
IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer. |
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| Journal |
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| LinkDB |
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