Entry Name Definition 4-ABP -- CYP1A2 >> NAT1 -> N-OAc-ABP == DNA
Expanded C10998 -- 1544 >> 9 -> C03621 == C00039
Class nt06250 DNA adduct formation (cancer)
Type Env factor
Pathway hsa05204 Chemical carcinogenesis - DNA adducts
Disease Gene 1544 CYP1A2; cytochrome P450 family 1 subfamily A member 2
9 NAT1; N-acetyltransferase 1
Perturbant C10998 (4-ABP) 4-Aminobiphenyl
Metabolite C03621 N-Acetoxy-4-aminobiphenyl
Reference Authors Kawanishi S, Hiraku Y, Murata M, Oikawa S
Title The role of metals in site-specific DNA damage with reference to carcinogenesis.
Journal Reference Authors Talaska G, al-Juburi AZ, Kadlubar FF
Title Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct.
Journal Reference Authors Frederickson SM, Hatcher JF, Reznikoff CA, Swaminathan S
Title Acetyl transferase-mediated metabolic activation of N-hydroxy-4-aminobiphenyl by human uroepithelial cells.
Journal Reference Authors Besaratinia A, Tommasi S
Title Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions.
Journal LinkDB All DBs
