Entry Name Definition PhIP -- CYP1A2 >> NAT2 -> N-OAc-PhIP == DNA
Expanded C16038 -- 1544 >> 10 -> C20287 == C00039
Class nt06250 DNA adduct formation (cancer)
Type Env factor
Pathway hsa05204 Chemical carcinogenesis - DNA adducts
Disease Gene 1544 CYP1A2; cytochrome P450 family 1 subfamily A member 2
10 NAT2; N-acetyltransferase 2
Perturbant C16038 (PhIP) 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Metabolite C20287 2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Reference Authors Patterson AD, Gonzalez FJ, Idle JR
Title Xenobiotic metabolism: a view through the metabolometer.
Journal Reference Authors Snyderwine EG, Venugopal M, Yu M
Title Mammary gland carcinogenesis by food-derived heterocyclic amines and studies on the mechanisms of carcinogenesis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Journal Reference Authors Snyderwine EG
Title Mammary gland carcinogenesis by food-derived heterocyclic amines: metabolism and additional factors influencing carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Journal Reference Authors Williams JA, Phillips DH
Title Mammary expression of xenobiotic metabolizing enzymes and their potential role in breast cancer.
Journal Cancer Res 60:4667-77 (2000)
Reference Authors Dubuisson JG, Gaubatz JW
Title Bioactivation of the proximal food mutagen 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) to DNA-binding species by human mammary gland enzymes.
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