Entry Name Definition NMDA -- CYP2E1 -> C20301 -> C20302 -- DNA
Expanded C14704 -- 1571 -> C20301 -> C20302 -- C00039
Class Type Env factor
Pathway hsa05204 Chemical carcinogenesis - DNA adducts
Disease H00048 Hepatocellular carcinoma
Gene 1571 CYP2E1; cytochrome P450 family 2 subfamily E member 1
Perturbant C14704 (NMDA) N-Nitrosodimethylamine
Metabolite Reference Authors Lee VM, Keefer LK, Archer MC
Title An evaluation of the roles of metabolic denitrosation and alpha-hydroxylation in the hepatotoxicity of N-Nitrosodimethylamine.
Journal Reference Authors Encell L, Foiles PG, Gold B
Title The relationship between N-nitrosodimethylamine metabolism and DNA methylation in isolated rat hepatocytes.
Journal Reference Authors Kyrtopoulos SA
Title DNA adducts in humans after exposure to methylating agents.
Journal Reference Authors Sulc M, Hodek P, Stiborova M
Title The binding affinity of carcinogenic N-nitrosodimethylamine and N-nitrosomethylaniline to cytochromes P450 2B4, 2E1 and 3A6 does not dictate the rate of their enzymatic N-demethylation.
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