KEGG   NETWORK: N01383
Entry
N01383                      Network                                
Name
NDMA to DNA adducts
Definition
NMDA -- CYP2E1 -> C20301 -> C20302 -- DNA
  Expanded
C14704 -- 1571 -> C20301 -> C20302 -- C00039
Class
nt06250 DNA adduct formation
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00048  Hepatocellular carcinoma
Gene
1571  CYP2E1; cytochrome P450 family 2 subfamily E member 1
Perturbant
C14704 (NMDA)  N-Nitrosodimethylamine
Metabolite
C20301  alpha-Hydroxy-NDMA
C20302  Methyldiazonium ion
C00039  DNA
Reference
PMID:8951235
  Authors
Lee VM, Keefer LK, Archer MC
  Title
An evaluation of the roles of metabolic denitrosation and alpha-hydroxylation in the hepatotoxicity of N-Nitrosodimethylamine.
  Journal
Chem Res Toxicol 9:1319-24 (1996)
DOI:10.1021/tx960077u
Reference
PMID:8640923
  Authors
Encell L, Foiles PG, Gold B
  Title
The relationship between N-nitrosodimethylamine metabolism and DNA methylation in isolated rat hepatocytes.
  Journal
Carcinogenesis 17:1127-34 (1996)
DOI:10.1093/carcin/17.5.1127
Reference
PMID:9748543
  Authors
Kyrtopoulos SA
  Title
DNA adducts in humans after exposure to methylating agents.
  Journal
Mutat Res 405:135-43 (1998)
DOI:10.1016/s0027-5107(98)00130-4
Reference
  Authors
Sulc M, Hodek P, Stiborova M
  Title
The binding affinity of carcinogenic N-nitrosodimethylamine and N-nitrosomethylaniline to cytochromes P450 2B4, 2E1 and 3A6 does not dictate the  rate of their enzymatic N-demethylation.
  Journal
Gen Physiol Biophys 29:175-85 (2010)
DOI:10.4149/gpb_2010_02_175
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