KEGG   NETWORK: N01396
Entry
N01396                      Network                                
Name
4-Aminobiphenyl to CYP-mediated metabolism
Definition
4-ABP -- CYP1A2 -> C03622 -> Cu -> Superoxide
  Expanded
C10998 -- 1544 -> C03622 -> C00070 -> C00704
Class
nt06251 CYP-mediated ROS formation
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00022  Bladder cancer
Gene
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2
Perturbant
C10998 (4-ABP)  4-Aminobiphenyl
Metabolite
C03622  N-Hydroxy-4-aminobiphenyl
C00070  Copper
C00704  Superoxide
Reference
  Authors
Kawanishi S, Hiraku Y, Murata M, Oikawa S
  Title
The role of metals in site-specific DNA damage with reference to carcinogenesis.
  Journal
Free Radic Biol Med 32:822-32 (2002)
DOI:10.1016/S0891-5849(02)00779-7
Reference
  Authors
Murata M, Tamura A, Tada M, Kawanishi S
  Title
Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl.
  Journal
Free Radic Biol Med 30:765-73 (2001)
DOI:10.1016/S0891-5849(01)00463-4
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