KEGG   NETWORK: N01399
Entry
N01399                      Network                                
Name
Benzene to CYP-mediated metabolism
Definition
BZ -- (CYP2E1,CYP2F1) -> C01782 -> Phenol -- CYP2E1 -> HQ -> Cu -> Superoxide
  Expanded
C01407 -- (1571,1572) -> C01782 -> C00146 -- 1571 -> C00530 -> C00070 -> C00704
Class
nt06251 CYP-mediated ROS formation (cancer)
Type
Env factor
Pathway
hsa05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00003  Acute myeloid leukemia
Gene
1571  CYP2E1; cytochrome P450 family 2 subfamily E member 1
1572  CYP2F1; cytochrome P450 family 2 subfamily F member 1
Perturbant
C01407 (BZ)  Benzene
Metabolite
C01782  Benzene oxide
C00146  Phenol
C00530  Hydroquinone
C00070  Copper
C00704  Superoxide
Reference
  Authors
McHale CM, Zhang L, Smith MT
  Title
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment.
  Journal
Carcinogenesis 33:240-52 (2012)
DOI:10.1093/carcin/bgr297
Reference
  Authors
Scharf P, Broering MF, Oliveira da Rocha GH, Farsky SHP
  Title
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis.
  Journal
Int J Mol Sci 21:E6996 (2020)
DOI:10.3390/ijms21196996
Reference
PMID:9118888
  Authors
Snyder R, Hedli CC
  Title
An overview of benzene metabolism.
  Journal
Environ Health Perspect 104 Suppl 6:1165-71 (1996)
DOI:10.1289/ehp.961041165
Reference
  Authors
Kawanishi S, Hiraku Y, Murata M, Oikawa S
  Title
The role of metals in site-specific DNA damage with reference to carcinogenesis.
  Journal
Free Radic Biol Med 32:822-32 (2002)
DOI:10.1016/S0891-5849(02)00779-7
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