Entry |
|
Name |
Benzene to CYP-mediated metabolism
|
Definition |
BZ -- (CYP2E1,CYP2F1) -> C01782 -> Phenol -- CYP2E1 -> HQ -> Cu -> Superoxide |
Expanded |
C01407 -- (1571,1572) -> C01782 -> C00146 -- 1571 -> C00530 -> C00070 -> C00704 |
Class |
nt06251 CYP-mediated ROS formation (cancer)
|
Type |
Env factor
|
Pathway |
hsa05208 | Chemical carcinogenesis - reactive oxygen species |
|
Disease |
|
Gene |
1571 | CYP2E1; cytochrome P450 family 2 subfamily E member 1 |
1572 | CYP2F1; cytochrome P450 family 2 subfamily F member 1 |
|
Perturbant |
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Metabolite |
|
Reference |
|
Authors |
McHale CM, Zhang L, Smith MT |
Title |
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. |
Journal |
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Reference |
|
Authors |
Scharf P, Broering MF, Oliveira da Rocha GH, Farsky SHP |
Title |
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis. |
Journal |
|
Reference |
|
Authors |
Snyder R, Hedli CC |
Title |
An overview of benzene metabolism. |
Journal |
|
Reference |
|
Authors |
Kawanishi S, Hiraku Y, Murata M, Oikawa S |
Title |
The role of metals in site-specific DNA damage with reference to carcinogenesis. |
Journal |
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LinkDB |
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