| Entry |
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| Name |
Benzene to CYP-mediated metabolism
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| Definition |
BZ -- (CYP2E1,CYP2F1) -> C01782 -> Phenol -- CYP2E1 -> HQ -> C02389 -> Superoxide |
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| Expanded |
C01407 -- (1571,1572) -> C01782 -> C00146 -- 1571 -> C00530 -> C02389 -> C00704 |
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| Class |
nt06251 CYP-mediated ROS formation (cancer)
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| Type |
Env factor
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| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
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| Disease |
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| Gene |
| 1571 | CYP2E1; cytochrome P450 family 2 subfamily E member 1 |
| 1572 | CYP2F1; cytochrome P450 family 2 subfamily F member 1 |
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| Perturbant |
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| Metabolite |
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| Reference |
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| Authors |
McHale CM, Zhang L, Smith MT |
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| Title |
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. |
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| Journal |
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| Reference |
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| Authors |
Scharf P, Broering MF, Oliveira da Rocha GH, Farsky SHP |
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| Title |
Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis. |
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| Journal |
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| Reference |
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| Authors |
Snyder R, Hedli CC |
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| Title |
An overview of benzene metabolism. |
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| Journal |
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| Reference |
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| Authors |
Kawanishi S, Hiraku Y, Murata M, Oikawa S |
|---|
| Title |
The role of metals in site-specific DNA damage with reference to carcinogenesis. |
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| Journal |
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| LinkDB |
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