| Entry |
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| Name |
17beta-estradiol to CYP-mediated metabolism
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| Definition |
E2 -- CYP1A1 >> LPO -> C05309 -> Superoxide |
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| Expanded |
C00951 -- 1543 >> 4025 -> C05309 -> C00704 |
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| Class |
nt06251 CYP-mediated ROS formation (cancer)
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| Type |
Env factor
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| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
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| Disease |
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| Gene |
| 1543 | CYP1A1; cytochrome P450 family 1 subfamily A member 1 |
| 4025 | LPO; lactoperoxidase |
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| Perturbant |
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| Metabolite |
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| Reference |
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| Authors |
Cavalieri EL, Stack DE, Devanesan PD, Todorovic R, Dwivedy I, Higginbotham S, Johansson SL, Patil KD, Gross ML, Gooden JK, Ramanathan R, Cerny RL, Rogan EG |
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| Title |
Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. |
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| Journal |
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| Reference |
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| Authors |
Zhu BT, Conney AH |
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| Title |
Functional role of estrogen metabolism in target cells: review and perspectives. |
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| Journal |
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| Reference |
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| Authors |
Yager JD |
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| Title |
Endogenous estrogens as carcinogens through metabolic activation. |
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| Journal |
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| Reference |
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| Authors |
Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL |
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| Title |
Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. |
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| Journal |
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| LinkDB |
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