KEGG   NETWORK: N01416
Entry
N01416                      Network                                
Name
Mercury to NEP-mediated Abeta degradation
Definition
Hg -| NEP
  Expanded
C01319 -| 4311
Class
nt06460 Alzheimer disease
Type
Env factor
Pathway
hsa05010  Alzheimer disease
Disease
H00056  Alzheimer disease
Gene
4311  MME; membrane metalloendopeptidase
Perturbant
C01319 (Hg)  Hg
Reference
  Authors
Chin-Chan M, Segovia J, Quintanar L, Arcos-Lopez T, Hersh LB, Chow KM, Rodgers DW, Quintanilla-Vega B
  Title
Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells.
  Journal
Toxicol Sci 145:128-37 (2015)
DOI:10.1093/toxsci/kfv037
Reference
  Authors
Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B
  Title
Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases.
  Journal
Front Cell Neurosci 9:124 (2015)
DOI:10.3389/fncel.2015.00124
Reference
  Authors
Rahman MA, Rahman MS, Uddin MJ, Mamum-Or-Rashid ANM, Pang MG, Rhim H
  Title
Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases.
  Journal
Environ Sci Pollut Res Int 27:44659-44672 (2020)
DOI:10.1007/s11356-020-08243-z
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