KEGG   NETWORK: N01448
Entry
N01448                      Network                                
Name
Double Holliday junction resolution
Definition
SLX == MUS81+EME1 == GEN1
  Expanded
548593+79008+84464 == 80198+146956 == 348654
Class
nt06506 Double-strand break repair
Type
Reference
Pathway
hsa03460  Fanconi anemia pathway
Gene
548593  SLX1A; SLX1 homolog A, structure-specific endonuclease subunit
79008  SLX1B; SLX1 homolog B, structure-specific endonuclease subunit
84464  SLX4; SLX4 structure-specific endonuclease subunit
80198  MUS81; MUS81 structure-specific endonuclease subunit
146956  EME1; essential meiotic structure-specific endonuclease 1
348654  GEN1; GEN1 Holliday junction 5' flap endonuclease
Reference
  Authors
Scully R, Panday A, Elango R, Willis NA
  Title
DNA double-strand break repair-pathway choice in somatic mammalian cells.
  Journal
Nat Rev Mol Cell Biol 20:698-714 (2019)
DOI:10.1038/s41580-019-0152-0
Reference
  Authors
Sarbajna S, Davies D, West SC
  Title
Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.
  Journal
Genes Dev 28:1124-36 (2014)
DOI:10.1101/gad.238303.114
Reference
  Authors
Mota MBS, Carvalho MA, Monteiro ANA, Mesquita RD
  Title
DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens.
  Journal
Parasit Vectors 12:533 (2019)
DOI:10.1186/s13071-019-3792-1
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