KEGG   NETWORK: N01459
Entry
N01459                      Network                                
Name
Nodal signaling pathway
Definition
NODAL -> ((ACVR2A,ACVR2B)+(ACVR1B,ACVR1C)) -> (SMAD2,SMAD3) == SMAD4
  Expanded
4838 -> ((92,93)+(91,130399)) -> (4087,4088) == 4089
Class
nt06507 TGFB signaling
Type
Reference
Pathway
hsa04350  TGF-beta signaling pathway
Gene
4838  NODAL; nodal growth differentiation factor
92  ACVR2A; activin A receptor type 2A
93  ACVR2B; activin A receptor type 2B
91  ACVR1B; activin A receptor type 1B
130399  ACVR1C; activin A receptor type 1C
4087  SMAD2; SMAD family member 2
4088  SMAD3; SMAD family member 3
4089  SMAD4; SMAD family member 4
Reference
  Authors
Massague J, Blain SW, Lo RS
  Title
TGFbeta signaling in growth control, cancer, and heritable disorders.
  Journal
Cell 103:295-309 (2000)
DOI:10.1016/s0092-8674(00)00121-5
Reference
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
LinkDB

DBGET integrated database retrieval system