| Entry |
|
|---|
| Name |
Alternative pathway of complement cascade, C3b breakdown
|
|---|
| Definition |
(C3b+Bb) -- (CFH,(CD55+CR1)) -> C3b -- (CFI+(CFH,CR1,CD46)) -> iC3b -- (CFI+CR1) -> C3dg -- Plasmin -> C3d |
|---|
| Expanded |
(C22533+C22540) -- (3075,(1604+1378)) -> C22533 -- (3426+(3075,1378,4179)) -> C22535 -- (3426+1378) -> C22536 -- C00471 -> C22538 |
|---|
| Class |
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|---|
| Type |
Reference
|
|---|
| Pathway |
| hsa04610 | Complement and coagulation cascades |
|
|---|
| Gene |
| 3075 | CFH; complement factor H |
| 1604 | CD55; CD55 molecule (Cromer blood group) |
| 1378 | CR1; complement C3b/C4b receptor 1 (Knops blood group) |
| 3426 | CFI; complement factor I |
|
|---|
| Metabolite |
| C22533 | Complement component 3b |
| C22536 | Complement component 3dg |
| C22538 | Complement component 3d |
|
|---|
| Reference |
|
|---|
| Authors |
Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT |
|---|
| Title |
Complement System Part I - Molecular Mechanisms of Activation and Regulation. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Mastellos DC, Ricklin D, Lambris JD |
|---|
| Title |
Clinical promise of next-generation complement therapeutics. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Kouser L, Abdul-Aziz M, Nayak A, Stover CM, Sim RB, Kishore U |
|---|
| Title |
Properdin and factor h: opposing players on the alternative complement pathway "see-saw". |
|---|
| Journal |
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| LinkDB |
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