| Entry |
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| Symbol |
CFI, AHUS3, ARMD13, C3BINA, C3b-INA, FI, IF, KAF
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| Name |
(RefSeq) complement factor I
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| KO |
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| Organism |
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| Pathway |
| hsa04610 | Complement and coagulation cascades |
| hsa05150 | Staphylococcus aureus infection |
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| Network |
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| Element |
| N01495 | Classical/Lectin pathway of complement cascade, C4b breakdown |
| N01496 | Alternative pathway of complement cascade, C3b breakdown |
| N01527 | KSHV Kaposin to classical/Lectin pathway of complement cascade, C4b breakdown |
| N01528 | KSHV Kaposin to alternative pathway of complement cascade, C3b breakdown |
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| Disease |
| H00106 | Complement regulatory protein defects |
| H00821 | Age-related macular degeneration |
| H01434 | Atypical hemolytic uremic syndrome |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
3426 (CFI)
09160 Human Diseases
09171 Infectious disease: bacterial
05150 Staphylococcus aureus infection
3426 (CFI)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:hsa01002]
3426 (CFI)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
3426 (CFI)
Enzymes [BR:hsa01000]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.45 complement factor I
3426 (CFI)
Peptidases and inhibitors [BR:hsa01002]
Serine peptidases
Family S1: chymotrypsin family
3426 (CFI)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
3426 (CFI)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
4:complement(109730982..109801999)
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| AA seq |
583 aa
MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV
CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN
TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE
CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA
CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVT
QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA
SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN
YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER
VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV
WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV |
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| NT seq |
1752 nt +upstreamnt +downstreamnt
atgaagcttcttcatgttttcctgttatttctgtgcttccacttaaggttttgcaaggtc
acttatacatctcaagaggatctggtggagaaaaagtgcttagcaaaaaaatatactcac
ctctcctgcgataaagtcttctgccagccatggcagagatgcattgagggcacctgtgtt
tgtaaactaccgtatcagtgcccaaagaatggcactgcagtgtgtgcaactaacaggaga
agcttcccaacatactgtcaacaaaagagtttggaatgtcttcatccagggacaaagttt
ttaaataacggaacatgcacagccgaaggaaagtttagtgtttccttgaagcatggaaat
acagattcagagggaatagttgaagtaaaacttgtggaccaagataagacaatgttcata
tgcaaaagcagctggagcatgagggaagccaacgtggcctgccttgaccttgggtttcaa
caaggtgctgatactcaaagaaggtttaagttgtctgatctctctataaattccactgaa
tgtctacatgtgcattgccgaggattagagaccagtttggctgaatgtacttttactaag
agaagaactatgggttaccaggatttcgctgatgtggtttgttatacacagaaagcagat
tctccaatggatgacttctttcagtgtgtgaatgggaaatacatttctcagatgaaagcc
tgtgatggtatcaatgattgtggagaccaaagtgatgaactgtgttgtaaagcatgccaa
ggcaaaggcttccattgcaaatcgggtgtttgcattccaagccagtatcaatgcaatggt
gaggtggactgcattacaggggaagatgaagttggctgtgcaggctttgcatctgtgact
caagaagaaacagaaattttgactgctgacatggatgcagaaagaagacggataaaatca
ttattacctaaactatcttgtggagttaaaaacagaatgcacattcgaaggaaacgaatt
gtgggaggaaagcgagcacaactgggagacctcccatggcaggtggcaattaaggatgcc
agtggaatcacctgtgggggaatttatattggtggctgttggattctgactgctgcacat
tgtctcagagccagtaaaactcatcgttaccaaatatggacaacagtagtagactggata
caccccgaccttaaacgtatagtaattgaatacgtggatagaattattttccatgaaaac
tacaatgcaggcacttaccaaaatgacatcgctttgattgaaatgaaaaaagacggaaac
aaaaaagattgtgagctgcctcgttccatccctgcctgtgtcccctggtctccttaccta
ttccaacctaatgatacatgcatcgtttctggctggggacgagaaaaagataacgaaaga
gtcttttcacttcagtggggtgaagttaaactaataagcaactgctctaagttttacgga
aatcgtttctatgaaaaagaaatggaatgtgcaggtacatatgatggttccatcgatgcc
tgtaaaggggactctggaggccccttagtctgtatggatgccaacaatgtgacttatgtc
tggggtgttgtgagttggggggaaaactgtggaaaaccagagttcccaggtgtttacacc
aaagtggccaattattttgactggattagctaccatgtaggaaggccttttatttctcag
tacaatgtataa |
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