KEGG   NETWORK: N01530
Entry
N01530                      Network                                
Name
Dopamine metabolism
Definition
Tyr+BH4 -- TH -> L-Dopa -- DDC -> Dopamine -- MAO -> DOPAL
  Expanded
(C00082+C00272) -- 7054 -> C00355 -- 1644 -> C03758 -- (4128,4129) -> C04043
Class
nt06028 Dopamine and serotonin metabolism
nt06544 Neuroactive ligand signaling
nt06463 Parkinson disease
Type
Reference
Pathway
hsa00350  Tyrosine metabolism
hsa04728  Dopaminergic synapse
Gene
7054  TH; tyrosine hydroxylase
1644  DDC; dopa decarboxylase
4128  MAOA; monoamine oxidase A
4129  MAOB; monoamine oxidase B
Metabolite
C00082  L-Tyrosine
C00272  Tetrahydrobiopterin
C00355  3,4-Dihydroxy-L-phenylalanine
C03758  Dopamine
C04043  3,4-Dihydroxyphenylacetaldehyde
Reference
PMID:24548101
  Authors
Segura-Aguilar J, Paris I, Munoz P, Ferrari E, Zecca L, Zucca FA
  Title
Protective and toxic roles of dopamine in Parkinson's disease.
  Journal
J Neurochem 129:898-915 (2014)
DOI:10.1111/jnc.12686
Reference
PMID:24409201
  Authors
Jones DR, Moussaud S, McLean P
  Title
Targeting heat shock proteins to modulate alpha-synuclein toxicity.
  Journal
Ther Adv Neurol Disord 7:33-51 (2014)
DOI:10.1177/1756285613493469
Reference
PMID:31351996
  Authors
Burbulla LF, Krainc D
  Title
The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease.
  Journal
Neurobiol Dis 132:104545 (2019)
DOI:10.1016/j.nbd.2019.104545
Reference
PMID:28761417
  Authors
Segura-Aguilar J
  Title
On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease.
  Journal
Neural Regen Res 12:897-901 (2017)
DOI:10.4103/1673-5374.208560
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