Homo sapiens (human): 4129
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Entry
4129 CDS
T01001
Symbol
MAOB
Name
(RefSeq) monoamine oxidase B
KO
K00274
monoamine oxidase [EC:
1.4.3.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00260
Glycine, serine and threonine metabolism
hsa00330
Arginine and proline metabolism
hsa00340
Histidine metabolism
hsa00350
Tyrosine metabolism
hsa00360
Phenylalanine metabolism
hsa00380
Tryptophan metabolism
hsa00982
Drug metabolism - cytochrome P450
hsa01100
Metabolic pathways
hsa04726
Serotonergic synapse
hsa04728
Dopaminergic synapse
hsa05012
Parkinson disease
hsa05030
Cocaine addiction
hsa05031
Amphetamine addiction
hsa05034
Alcoholism
Module
hsa_M00135
GABA biosynthesis, eukaryotes, putrescine => GABA
Network
nt06028
Dopamine and serotonin metabolism
nt06463
Parkinson disease
Element
N01039
Mutation-inactivated PRKN to DOPAL generation
N01530
Dopamine metabolism
N01550
Adrenaline metabolism
N01551
Serotonin metabolism
Drug target
Caroxazone:
D03409
Etryptamine acetate:
D04092
Iproclozide:
D07338
Iproniazide (
DG00950
):
D02579
D08085
Isocarboxazid:
D02580
<US>
Ladostigil tartrate:
D03239
Lazabemide (
DG01259
):
D01097
D04681
Milacemide hydrochloride:
D05033
Mofegiline hydrochloride:
D03733
Nialamide:
D07337
Pargyline (
DG00264
):
D02564
D08453
Phenelzine (
DG00948
):
D00505
<US>
D08349
Phentermine (
DG00102
):
D05458
D05459
<US>
Rasagiline (
DG00865
):
D02562
<JP/US>
D08469
D10829
Safinamide (
DG01260
):
D10158
D10191
<JP/US>
Safrazine hydrochloride:
D01888
Selegiline (
DG00864
):
D00785
<JP/US>
D03731
<US>
Sembragiline:
D11224
Tranylcypromine (
DG00949
):
D00826
<US>
D08625
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
4129 (MAOB)
00330 Arginine and proline metabolism
4129 (MAOB)
00340 Histidine metabolism
4129 (MAOB)
00350 Tyrosine metabolism
4129 (MAOB)
00360 Phenylalanine metabolism
4129 (MAOB)
00380 Tryptophan metabolism
4129 (MAOB)
09111 Xenobiotics biodegradation and metabolism
00982 Drug metabolism - cytochrome P450
4129 (MAOB)
09150 Organismal Systems
09156 Nervous system
04728 Dopaminergic synapse
4129 (MAOB)
04726 Serotonergic synapse
4129 (MAOB)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
4129 (MAOB)
09165 Substance dependence
05030 Cocaine addiction
4129 (MAOB)
05031 Amphetamine addiction
4129 (MAOB)
05034 Alcoholism
4129 (MAOB)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.4 Acting on the CH-NH2 group of donors
1.4.3 With oxygen as acceptor
1.4.3.4 monoamine oxidase
4129 (MAOB)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Amino_oxidase
NAD_binding_8
DAO
FAD_oxidored
FAD_binding_2
Pyr_redox_2
FAD_binding_3
Thi4
Pyr_redox
HI0933_like
AlaDh_PNT_C
Pyr_redox_3
GIDA
IlvN
Lycopene_cycl
TrkA_N
MurD-like_N
MCRA
NAD_binding_9
Motif
Other DBs
NCBI-GeneID:
4129
NCBI-ProteinID:
NP_000889
OMIM:
309860
HGNC:
6834
Ensembl:
ENSG00000069535
Pharos:
P27338
(Tclin)
UniProt:
P27338
Structure
PDB
PDBj
LinkDB
All DBs
Position
X:complement(43766610..43882450)
Genome browser
AA seq
520 aa
AA seq
DB search
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
NT seq
1563 nt
NT seq
+upstream
nt +downstream
nt
atgagcaacaaatgcgacgtggtcgtggtggggggcggcatctcaggtatggcagcagcc
aaacttctgcatgactctggactgaatgtggttgttctggaagcccgggaccgtgtggga
ggcaggacttacactcttaggaaccaaaaggttaaatatgtggaccttggaggatcctat
gttggaccaacccagaatcgtatcttgagattagccaaggagctaggattggagacctac
aaagtgaatgaggttgagcgtctgatccaccatgtaaagggcaaatcataccccttcagg
gggccattcccacctgtatggaatccaattacctacttagatcataacaacttttggagg
acaatggatgacatggggcgagagattccgagtgatgccccatggaaggctccccttgca
gaagagtgggacaacatgacaatgaaggagctactggacaagctctgctggactgaatct
gcaaagcagcttgccactctctttgtgaacctgtgtgtcactgcagagacccatgaggtc
tctgctctctggttcctgtggtatgtgaagcagtgtggaggcacaacaagaatcatctcg
acaacaaatggaggacaggagaggaaatttgtgggcggatctggtcaagtgagtgagcgg
ataatggacctccttggagaccgagtgaagctggagaggcctgtgatctacattgaccag
acaagagaaaatgtccttgtggagaccctaaaccatgagatgtatgaggctaaatatgtg
attagtgctattcctcctactctgggcatgaagattcacttcaatccccctctgccaatg
atgagaaaccagatgatcactcgtgtgcctttgggttcagtcatcaagtgtatagtttat
tataaagagcctttctggaggaaaaaggattactgtggaaccatgattattgatggagaa
gaagctccagttgcctacacgttggatgataccaaacctgaaggcaactatgctgccata
atgggatttatcctggcccacaaagccagaaaactggcacgtcttaccaaagaggaaagg
ttgaagaaactttgtgaactctatgccaaggttctgggttccctagaagctctggagcca
gtgcattatgaagaaaagaactggtgtgaggagcagtactctgggggctgctacacaact
tatttcccccctgggatcctgactcaatatggaagggttctacgccagccagtggacagg
atttactttgcaggcaccgagactgccacacactggagcggctacatggagggggctgta
gaggccggggagagagcagcccgagagatcctgcatgccatggggaagattccagaggat
gaaatctggcagtcagaaccagagtctgtggatgtccctgcacagcccatcaccaccacc
tttttggagagacatttgccctccgtgccaggcctgctcaggctgattggattgaccacc
atcttttcagcaacggctcttggcttcctggcccacaaaagggggctacttgtgagagtc
taa
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