KEGG   NETWORK: N01584
Entry
N01584                      Network                                
Name
FLCN-mTORC1 signaling pathway
Definition
(SLC7A5+SLC3A2) -> FLCN -> RRAGA/B/C/D -> mTORC1
  Expanded
(8140+6520) -> 201163 -> (10670+10325+64121+58528) -> (2475+57521+84335+64798+64223+9894+9675)
Class
nt06522 mTOR signaling
Type
Reference
Pathway
hsa04150  mTOR signaling pathway
Gene
8140  SLC7A5; solute carrier family 7 member 5
6520  SLC3A2; solute carrier family 3 member 2
201163  FLCN; folliculin
10670  RRAGA; Ras related GTP binding A
10325  RRAGB; Ras related GTP binding B
64121  RRAGC; Ras related GTP binding C
58528  RRAGD; Ras related GTP binding D
2475  MTOR; mechanistic target of rapamycin kinase
57521  RPTOR; regulatory associated protein of MTOR complex 1
84335  AKT1S1; AKT1 substrate 1
64798  DEPTOR; DEP domain containing MTOR interacting protein
64223  MLST8; MTOR associated protein, LST8 homolog
9894  TELO2; telomere maintenance 2
9675  TTI1; TELO2 interacting protein 1
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
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