| Entry |
|
|---|
| Name |
Branched-chain amino acids degradation 2
|
|---|
| Definition |
[KIC,KIV,KMV]+Lipoyl-E2 -- BCKDH >> DBT -> [IV-CoA,IB-CoA,2-MB-CoA]+Dihydrolipoyl-E2 |
|---|
| Expanded |
[C00233,C00141,C00671]+C15972 -- (593+594) >> 1629 -> [C02939,C00630,C15980]+C15973 |
|---|
| Class |
nt06024 Valine, leucine and isoleucine degradation
nt06032 Lipoic acid metabolism
|
|---|
| Type |
Reference
|
|---|
| Pathway |
| hsa00280 | Valine, leucine and isoleucine degradation |
|
|---|
| Gene |
| 593 | BCKDHA; branched chain keto acid dehydrogenase E1 subunit alpha |
| 594 | BCKDHB; branched chain keto acid dehydrogenase E1 subunit beta |
| 1629 | DBT; dihydrolipoamide branched chain transacylase E2 |
|
|---|
| Metabolite |
| C00233 | 4-Methyl-2-oxopentanoate |
| C00141 | 3-Methyl-2-oxobutanoic acid |
| C00671 | (S)-3-Methyl-2-oxopentanoic acid |
| C15972 | [E2 protein] N6-(lipoyl)lysine |
| C15980 | (S)-2-Methylbutanoyl-CoA |
| C15973 | [E2 protein] N6-(dihydrolipoyl)lysine |
|
|---|
| LinkDB |
|
|---|
