KEGG   NETWORK: N01663
Entry
N01663                      Network                                
Name
CASP8 regulation of RIPK1/3
Definition
CASP8 -| (RIPK1+RIPK3)
  Expanded
841 -| (8737+11035)
Class
nt06527 Necroptosis
Type
Reference
Pathway
hsa04217 Necroptosis   
Gene
841  CASP8; caspase 8
8737  RIPK1; receptor interacting serine/threonine kinase 1
11035  RIPK3; receptor interacting serine/threonine kinase 3
Reference
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
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