KEGG   NETWORK: N01679
Entry
N01679                      Network                                
Name
Pk and P antigens biosynthesis
Definition
LacCer -- A4GALT*P1 -> Pk -- B3GALNT1*P -> P // GBGT1*Fs-
  Expanded
G00092 -- 53947v1 -> G00093 -- 8706v1 -> G00094 // 26301v1
Class
nt06035 Blood group carbohydrate antigen biosynthesis
Type
Reference
Pathway
hsa00603  Glycosphingolipid biosynthesis - globo and isoglobo series
Gene
53947  A4GALT; alpha 1,4-galactosyltransferase (P blood group)
8706  B3GALNT1; beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
26301  GBGT1; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)
Variant
53947v1 (A4GALT*P1)  A4GALT P1+, Pk+ allele
8706v1 (B3GALNT1*P)  B3GALNT1 P+ allele
26301v1 (GBGT1*Fs-)  GBGT1 FORS- allele
Metabolite
G00092  Lactosylceramide
G00093  Globotriaosylceramide
G00094  Globoside
Reference
PMID:26773500
  Authors
Kaczmarek R, Duk M, Szymczak K, Korchagina E, Tyborowska J, Mikolajczyk K, Bovin N, Szewczyk B, Jaskiewicz E, Czerwinski M
  Title
Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating P(k), P1 and NOR  blood group antigens.
  Journal
Biochem Biophys Res Commun 470:168-174 (2016)
DOI:10.1016/j.bbrc.2016.01.017
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